Journal article
The newborn metabolome: associations with gestational diabetes, sex, gestation, birth mode, and birth weight
T Mansell, A Vlahos, F Collier, AL Ponsonby, P Vuillermin, S Ellul, MLK Tang, D Burgner, R Saffery
Pediatric Research | Published : 2022
Abstract
BACKGROUND: Pathways towards many adult-onset conditions begin early in life, even in utero. Maternal health in pregnancy influences this process, but little is known how it affects neonatal metabolism. We investigated associations between pregnancy and birth factors and cord blood metabolomic profile in a large, population-derived cohort. METHODS: Metabolites were measured using nuclear magnetic resonance in maternal (28 weeks gestation) and cord serum from 912 mother-child pairs in the Barwon Infant Study pre-birth cohort. Associations between maternal (metabolites, age, BMI, smoking), pregnancy (pre-eclampsia, gestational diabetes (GDM)), and birth characteristics (delivery mode, gestatio..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The establishment work and infrastructure for the BIS was provided by the Murdoch Children's Research Institute, Deakin University, and Barwon Health. Subsequent funding was secured from the National Health and Medical Research Council of Australia, The Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's Fund Raising Committee Barwon Health, The Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA Limited, the Percy Baxter Charitable Trust, and Perpetual Trustees. In-kind support was provided by the Cotton On Foundation and CreativeForce. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. This work was also supported by NHMRC Senior Research Fellowships (1008396 to A.-L.P.; 1064629 to D.B.; 1045161 to R.S.) and NHMRC Investigator Grants to A.-L.P. (1110200) and D.B. (1175744). Funders did not participate in the work or writing of this manuscript.